Graphite oxide catalyzed synthesis of β -amino alcohols by ring-opening of epoxides

نویسندگان

  • Maryam MIRZA-AGHAYAN
  • Farzaneh ALVANDI
  • Mahdieh MOLAEE TAVANA
  • Rabah BOUKHERROUB
چکیده

Graphite oxide as a heterogeneous and recyclable solid acid catalyzed a simple and efficient method for the synthesis of β -amino alcohols by ring opening of epoxides with amines. This method is effective with various aromatic and aliphatic amines under solvent-free conditions. The corresponding β -amino alcohols are obtained in high yields (56%–95%) and short reaction times (15–30 min) with high regioand chemoselectivity under metal-free conditions.

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تاریخ انتشار 2017